Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Epistasis between antibiotic resistance mutations and genetic background shape the fitness effect of resistance across species of Pseudomonas.

Proceedings. Biological sciences - 11 May 2016

Vogwill T, Kojadinovic M, MacLean R C

Abstract excerpt

Antibiotic resistance often evolves by mutations at conserved sites in essential genes, resulting in parallel molecular evolution between divergent bacterial strains and species. Whether these resistance mutations are having parallel effects on fitness across bacterial taxa, however, is unclear. This is an important point to address, because the fitness effects of resistance mutations play a key role in the...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to DNA-Directed RNA Polymerases
Share to Drug Resistance, Bacterial

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Epistasis, Genetic

Share to Gene Expression Regulation, Bacterial

Share to Mutation

Share to Phylogeny

Share to Pseudomonas

Share to Rifampin

Source

Open in PubMed Open full text

Identifiers

PMID: 27170722
DOI: 10.1098/rspb.2016.0151
PMCID: PMC4874708

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Epistasis between antibiotic resistance mutations and genetic background shape the fitness effect of resistance across species of Pseudomonas.PMID 27170722Read ↗

Pervasive genotype-by-environment interactions shape the fitness effects of antibiotic resistance mutations.Semantic proximity Read ↗

Linking system-wide impacts of RNA polymerase mutations to the fitness cost of rifampin resistance in Pseudomonas aeruginosa.Semantic proximity Read ↗

Epistasis buffers the fitness effects of rifampicin- resistance mutations in Pseudomonas aeruginosa.Semantic proximity Read ↗

Predictable Phenotypes of Antibiotic Resistance Mutations.Semantic proximity Read ↗

The distribution of fitness effects of beneficial mutations in Pseudomonas aeruginosa.Semantic proximity Read ↗

Diminishing returns from beneficial mutations and pervasive epistasis shape the fitness landscape for rifampicin resistance in Pseudomonas aeruginosa.Semantic proximity Read ↗

Evolution of Escherichia coli rifampicin resistance in an antibiotic-free environment during thermal stress.Semantic proximity Read ↗

Environmental Dependence of Competitive Fitness in Rifampin-Resistant rpoB Mutants of Bacillus subtilis.Semantic proximity Read ↗

Analysing the fitness cost of antibiotic resistance to identify targets for combination antimicrobials.Semantic proximity Read ↗

The fitness cost of rifampicin resistance in Pseudomonas aeruginosa depends on demand for RNA polymerase.Semantic proximity Read ↗

The cost of multiple drug resistance in Pseudomonas aeruginosa.Semantic proximity Read ↗

Environmental variation alters the fitness effects of rifampicin resistance mutations in Pseudomonas aeruginosa.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.