Article
Epistasis between antibiotic resistance mutations and genetic background shape the fitness effect of resistance across species of Pseudomonas.
Proceedings. Biological sciences - 11 May 2016
Vogwill T, Kojadinovic M, MacLean R C
Abstract excerpt
Antibiotic resistance often evolves by mutations at conserved sites in essential genes, resulting in parallel molecular evolution between divergent bacterial strains and species. Whether these resistance mutations are having parallel effects on fitness across bacterial taxa, however, is unclear....
Topics
- DNA-Directed RNA Polymerases
- Drug Resistance, Bacterial
- Epistasis, Genetic
- Gene Expression Regulation, Bacterial
- Mutation
- Phylogeny
- Pseudomonas
- Rifampin