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Article

The cost of multiple drug resistance in Pseudomonas aeruginosa.

Journal of evolutionary biology - 1 May 2009

Ward H, Perron G G, Maclean R C

Abstract excerpt

The spread of bacterial antibiotic resistance mutations is thought to be constrained by their pleiotropic fitness costs. Here we investigate the fitness costs of resistance in the context of the evolution of multiple drug resistance (MDR), by measuring the cost of acquiring streptomycin resistance mutations (StrepR) in independent strains of the bacterium Pseudomonas aeruginosa carrying different rifampicin...

Topics

Analysis of Variance
Biological Evolution
DNA Primers
Drug Resistance, Multiple, Bacterial
Epistasis, Genetic
Genetic Fitness
Mutation
Pseudomonas aeruginosa
Ribosomal Proteins
Rifampin
Sequence Analysis, DNA

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Streptomycin

Source

Identifiers

PMID: 19298493
DOI: 10.1111/j.1420-9101.2009.01712.x

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-19298493-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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