Diminishing returns from beneficial mutations and pervasive epistasis shape the fitness landscape for rifampicin resistance in Pseudomonas aeruginosa.

doi:10.1534/genetics.110.123083

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Article

Diminishing returns from beneficial mutations and pervasive epistasis shape the fitness landscape for rifampicin resistance in Pseudomonas aeruginosa.

Genetics - 1 Dec 2010

MacLean R C, Perron G G, Gardner A

Abstract excerpt

Because adaptation depends upon the fixation of novel beneficial mutations, the fitness effects of beneficial mutations that are substituted by selection are key to our understanding of the process of adaptation. In this study, we experimentally investigated the fitness effects of beneficial muta...

Topics

Biological Evolution
Drug Resistance, Microbial
Epistasis, Genetic
Genetic Fitness
Genotype
Mutation
Pseudomonas aeruginosa
Rifampin

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