Article
The distribution of fitness effects of beneficial mutations in Pseudomonas aeruginosa.
PLoS genetics - 1 Mar 2009
MacLean R Craig, Buckling Angus
Abstract excerpt
Understanding how beneficial mutations affect fitness is crucial to our understanding of adaptation by natural selection. Here, using adaptation to the antibiotic rifampicin in the opportunistic pathogen Pseudomonas aeruginosa as a model system, we investigate the underlying distribution of fitness effects of beneficial mutations on which natural selection acts. Consistent with theory, the effects of beneficial...
Topics
- Anti-Bacterial Agents
- DNA-Directed RNA Polymerases
- Mutation
- Phenotype
- Pseudomonas aeruginosa
- Rifampin
- Selection, Genetic