Epistasis buffers the fitness effects of rifampicin- resistance mutations in Pseudomonas aeruginosa.

doi:10.1111/j.1558-5646.2011.01302.x

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Article

Epistasis buffers the fitness effects of rifampicin- resistance mutations in Pseudomonas aeruginosa.

Evolution; international journal of organic evolution - 1 Aug 2011

Hall Alex R, MacLean R Craig

Abstract excerpt

Epistatic interactions between resistance mutations in antibiotic-free environments potentially play a crucial role in the spread of resistance in pathogen populations by determining the fitness cost associated with resistance. We used an experimental evolution approach to test for epistatic inte...

Topics

Adaptation, Physiological
Anti-Bacterial Agents
Biological Evolution
DNA-Directed RNA Polymerases
Drug Resistance, Microbial
Epistasis, Genetic
Genetic Fitness
Mutation
Pseudomonas aeruginosa
Rifampin

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