Article
Environmental variation alters the fitness effects of rifampicin resistance mutations in Pseudomonas aeruginosa.
Evolution; international journal of organic evolution - 1 Mar 2016
Gifford Danna R, Moss Ethan, MacLean R Craig
Abstract excerpt
The fitness effects of antibiotic resistance mutations in antibiotic-free conditions play a key role in determining the long-term maintenance of resistance. Although resistance is usually associated with a cost, the impact of environmental variation on the cost of resistance is poorly understood. Here, we test the impact of heterogeneity in temperature and resource availability on the fitness effects of...
Topics
- Biological Evolution
- DNA-Directed RNA Polymerases
- Drug Resistance, Bacterial
- Mutation
- Pseudomonas aeruginosa
- Rifampin
- Temperature