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Article

Impaired burrowing is the most prominent behavioral deficit of aging htau mice.

Neuroscience - 4 Aug 2016

Geiszler Philippine Camilla, Barron Matthew Richard, Pardon Marie-Christine

Abstract excerpt

htau mice are deficient of murine tau but express all six human tau isoforms, leading to gradual tau misprocessing and aggregation in brain areas relevant to Alzheimer's disease. While histopathological changes in htau mice have been researched in the past, we focused here on functional consequences of human tau accumulation. htau mice and their background controls - murine tau knock-out (mtau(-/-)) and C57Bl/6J...

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Identifiers

PMID: 27167086
DOI: 10.1016/j.neuroscience.2016.05.004
PMCID: PMC4915442

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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