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Article

The behavioural phenotype of 14-month-old female TAU58/2 transgenic mice.

Behavioural brain research - 15 Jan 2021

Kreilaus Fabian, Masanetz Rebecca, Watt Georgia, Przybyla Magdalena, Ittner Arne, Ittner Lars, Karl Tim

Abstract excerpt

Frontotemporal dementia (FTD) and Alzheimer's disease (AD) exhibit intracellular inclusions [neurofibrillary tangles (NFT's)] of microtubule-associated protein tau that contributes to neuronal dysfunction and death. Mutations in the microtubule-associated protein tau (MAPT) gene leads to tau hyperphosphorylation and promotes NFT formation. The TAU58/2 transgenic mouse model expresses mutant human tau (P301S...

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PMID: 33017638
DOI: 10.1016/j.bbr.2020.112943

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