Article
Spatial learning and memory impairment and increased locomotion in a transgenic amyloid precursor protein mouse model of Alzheimer's disease.
Behavioural brain research - 12 Sept 2011
Walker J M, Fowler S W, Miller D K, Sun A Y, Weisman G A, Wood W G, Sun G Y, Simonyi A, Schachtman T R
Abstract excerpt
This study provides an examination of spatial learning and a behavioral assessment of irritability and locomotion in TgCRND8 mice, an amyloid precursor protein transgenic model of Alzheimer's disease. Performance was assessed using the Barnes maze, the touch escape test, and an open-field test. While past research focused primarily on 2-5-month-old TgCRND8 mice, the present study used an older age cohort...
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