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Article

A longitudinal study of behavioral deficits in an AβPP transgenic mouse model of Alzheimer's disease.

Journal of Alzheimer's disease : JAD - 1 Jan 2011

Havas Daniel, Hutter-Paier Birgit, Ubhi Kiren, Rockenstein Edward, Crailsheim Karl, Masliah Eliezer, Windisch Manfred

Abstract excerpt

Elucidating the age-dependent alterations in transgenic (Tg) mice overexpressing amyloid-β protein precursor (AβPP) is important for understanding the pathogenesis of Alzheimer's disease (AD) and designing experimental therapies. Cross-studies have previously characterized some time-dependent behavioral and pathological alterations in AβPP Tg mice, however, a more comprehensive longitudinal study is needed to...

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Identifiers

PMID: 21403389
DOI: 10.3233/JAD-2011-101866
PMCID: PMC4944527

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