Article

Cognitive impairments in a mouse model for Huntington’s disease correlate with presymptomatic locomotion and number of CAG repeats

2026-07-22

Abstract excerpt

Huntington’s disease (HD) is a progressive neurodegenerative disorder caused by an expanded CAG repeat in the huntingtin ( HTT ) gene. The disease is characterized by movement disorders, and it also presents with personality changes, including apathy and aggression, along with cognitive decline. While most animal models for HD have been validated for motor deficits, less is known about alterations in other behav...

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Literature Corpus work: 3c9c1718-f138-566a-8a09-4a4032930b4a
DOI: 10.64898/2026.07.17.738914

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