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Article

The complete local genotype-phenotype landscape for the alternative splicing of a human exon.

Nature communications - 10 May 2016

Julien Philippe, Miñana Belén, Baeza-Centurion Pablo, Valcárcel Juan, Lehner Ben

Abstract excerpt

The properties of genotype-phenotype landscapes are crucial for understanding evolution but are not characterized for most traits. Here, we present a >95% complete local landscape for a defined molecular function-the alternative splicing of a human exon (FAS/CD95 exon 6, involved in the control of apoptosis). The landscape provides important mechanistic insights, revealing that regulatory information is dispersed...

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Identifiers

PMID: 27161764
DOI: 10.1038/ncomms11558
PMCID: PMC4866304

Genes

FAS

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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