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Article

Evolutionary accessibility of mutational pathways.

PLoS computational biology - 1 Aug 2011

Franke Jasper, Klözer Alexander, de Visser J Arjan G M, Krug Joachim

Abstract excerpt

Functional effects of different mutations are known to combine to the total effect in highly nontrivial ways. For the trait under evolutionary selection ('fitness'), measured values over all possible combinations of a set of mutations yield a fitness landscape that determines which mutational states can be reached from a given initial genotype. Understanding the accessibility properties of fitness landscapes is...

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Identifiers

PMID: 21876664
DOI: 10.1371/journal.pcbi.1002134
PMCID: PMC3158036

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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