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Article

The ascent of the abundant: how mutational networks constrain evolution.

PLoS computational biology - 18 Jul 2008

Cowperthwaite Matthew C, Economo Evan P, Harcombe William R, Miller Eric L, Meyers Lauren Ancel

Abstract excerpt

Evolution by natural selection is fundamentally shaped by the fitness landscapes in which it occurs. Yet fitness landscapes are vast and complex, and thus we know relatively little about the long-range constraints they impose on evolutionary dynamics. Here, we exhaustively survey the structural l...

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Identifiers

PMID: 18636097
DOI: 10.1371/journal.pcbi.1000110
PMCID: PMC2430528

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-18636097-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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