Gene-level complexity explains genome-wide variation in the distribution of fitness effects.

Abstract excerpt

The distribution of fitness effects (DFE)-describing how harmful, neutral, or beneficial new mutations are-is central to understanding how populations evolve. Although the DFE varies across genomes and species, it remains unclear which aspects of genomic organization drive this variation. Here, we inferred gene-level selective constraints across the genomes of Mus musculus castaneus, Drosophila melanogaster and...

Topics

• Animals
• Genetic Fitness
• Drosophila melanogaster
• Saccharomyces cerevisiae
• Mice
• Selection, Genetic
• Evolution, Molecular