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Article

Exercise training prevents ventricular tachycardia in CPVT1 due to reduced CaMKII-dependent arrhythmogenic Ca2+ release.

Cardiovascular research - 1 Aug 2016

Manotheepan Ravinea, Danielsen Tore K, Sadredini Mani, Anderson Mark E, Carlson Cathrine R, Lehnart Stephan E, Sjaastad Ivar, Stokke Mathis K

Abstract excerpt

AIMS: Catecholaminergic polymorphic ventricular tachycardia type 1 (CPVT1) is caused by mutations in the cardiac ryanodine receptor (RyR2) that lead to disrupted Ca(2+) handling in cardiomyocytes and ventricular tachycardia. The aim of this study was to test whether exercise training could reduce the propensity for arrhythmias in mice with the CPVT1-causative missense mutation Ryr2-R2474S by restoring normal...

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Share to Calcium-Calmodulin-Dependent Protein Kinase Type 2
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Identifiers

PMID: 27161030
DOI: 10.1093/cvr/cvw095
PMCID: PMC4957490

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Exercise training prevents ventricular tachycardia in CPVT1 due to reduced CaMKII-dependent arrhythmogenic Ca2+ release.PMID 27161030Read ↗

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