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Article

Ryanodine receptor-mediated arrhythmias and sudden cardiac death.

Pharmacology & therapeutics - 1 Aug 2009

Blayney Lynda M, Lai F Anthony

Abstract excerpt

The cardiac ryanodine receptor-Ca2+ release channel (RyR2) is an essential sarcoplasmic reticulum (SR) transmembrane protein that plays a central role in excitation-contraction coupling (ECC) in cardiomyocytes. Aberrant spontaneous, diastolic Ca2+ leak from the SR due to dysfunctional RyR2 contributes to the formation of delayed after-depolarisations, which are thought to underlie the fatal arrhythmia that occurs...

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Source

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Identifiers

PMID: 19345240
DOI: 10.1016/j.pharmthera.2009.03.006
PMCID: PMC2704947

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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