Article
Na+-dependent SR Ca2+ overload induces arrhythmogenic events in mouse cardiomyocytes with a human CPVT mutation.
Cardiovascular research - 1 Jul 2010
Sedej Simon, Heinzel Frank R, Walther Stefanie, Dybkova Nataliya, Wakula Paulina, Groborz Jan, Gronau Phillip, Maier Lars S, Vos Marc A, Lai F Anthony, Napolitano Carlo, Priori Silvia G, Kockskämper Jens, Pieske Burkert
Abstract excerpt
AIMS: Mutations in the cardiac ryanodine receptor Ca(2+) release channel, RyR2, underlie catecholaminergic polymorphic ventricular tachycardia (CPVT), an inherited life-threatening arrhythmia. CPVT is triggered by spontaneous RyR2-mediated sarcoplasmic reticulum (SR) Ca(2+) release in response to SR Ca(2+) overload during beta-adrenergic stimulation. However, whether elevated SR Ca(2+) content--in the absence of...
Topics
- Action Potentials
- Animals
- Calcium
- Calcium Signaling
- Catecholamines
- Enzyme Inhibitors
- Female
- Gene Knock-In Techniques
- Humans
- Male