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Article

Heterogeneity of ryanodine receptor dysfunction in a mouse model of catecholaminergic polymorphic ventricular tachycardia.

Circulation research - 18 Jan 2013

Loaiza Randall, Benkusky Nancy A, Powers Patricia P, Hacker Timothy, Noujaim Sami, Ackerman Michael J, Jalife José, Valdivia Héctor H

Abstract excerpt

RATIONALE: Most cardiac ryanodine receptor (RyR2) mutations associated with catecholaminergic polymorphic ventricular tachycardia (CPVT) are postulated to cause a distinctive form of Ca(2+) release dysfunction. Considering the spread distribution of CPVT mutations, we hypothesized that dysfunctional heterogeneity also was feasible. OBJECTIVE: To determine the molecular and cellular mechanisms by which a novel...

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Identifiers

PMID: 23152493
DOI: 10.1161/CIRCRESAHA.112.274803
PMCID: PMC3549355

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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