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Article

Compromised repolarization reserve in a murine model of catecholaminergic polymorphic ventricular tachycardia caused by RyR2-R420Q mutation.

Journal of molecular and cellular cardiology - 1 Sept 2025

Zissimopoulos Spyros, Kirilenko Pavel, Braza-Boïls Aitana, Zorio Esther, Wang Yueyi, Gomez Ana Maria, Cannell Mark B, Latinkic Branko, Fowler Ewan D

Abstract excerpt

BACKGROUND: Catecholaminergic polymorphic ventricular tachycardia (CPVT) is a malignant inherited heart disease characterised by stress-induced arrhythmias that are thought to be caused by delayed afterdepolarizations resulting from abnormal Ca2+ cycling. Some patients exhibit unusually large ECG U-waves that could be associated with altered ventricular repolarization, but the possible link with dysfunctional...

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Identifiers

PMID: 40714045
DOI: 10.1016/j.yjmcc.2025.07.014
PMCID: PMC7619069

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