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Article

Treatment of catecholaminergic polymorphic ventricular tachycardia in mice using novel RyR2-modifying drugs.

International journal of cardiology - 15 Jan 2017

Li Na, Wang Qiongling, Sibrian-Vazquez Martha, Klipp Robert C, Reynolds Julia O, Word Tarah A, Scott Larry, Salama Guy, Strongin Robert M, Abramson Jonathan J, Wehrens Xander H T

Abstract excerpt

RATIONALE: Catecholaminergic polymorphic ventricular tachycardia (CPVT) is a potentially lethal arrhythmic disorder caused by mutations in the type-2 ryanodine receptor (RyR2). Mutant RyR2 cause abnormal Ca2+ leak from the sarcoplasmic reticulum (SR), which is associated with the development of arrhythmias. OBJECTIVE: To determine whether derivatives of tetracaine, a local anesthetic drug with known RyR2...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Dose-Response Relationship, Drug

Share to Mice, Transgenic

Share to Polymorphic Catecholaminergic Ventricular Tachycardia

Share to Ryanodine Receptor Calcium Release Channel

Share to Tachycardia, Ventricular

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Source

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Identifiers

PMID: 27838126
DOI: 10.1016/j.ijcard.2016.10.078
PMCID: PMC5164850

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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