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Article

Exercise training improves cardiac function and attenuates arrhythmia in CPVT mice.

Journal of applied physiology (Bethesda, Md. : 1985) - 1 Dec 2012

Kurtzwald-Josefson Efrat, Hochhauser Edith, Katz Guy, Porat Eyal, Seidman Jonathan G, Seidman Christine E, Chepurko Yelena, Shainberg Asher, Eldar Michael, Arad Michael

Abstract excerpt

Catecholaminergic polymorphic ventricular tachycardia (CPVT) is a lethal ventricular arrhythmia evoked by physical or emotional stress. Recessively inherited CPVT is caused by either missense or null-allele mutations in the cardiac calsequestrin (CASQ2) gene. It was suggested that defects in CASQ...

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Share to Atrial Natriuretic Factor
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 23042908
DOI: 10.1152/japplphysiol.00818.2012
PMCID: PMC3774075

Genes

CASQ2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-23042908-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

Related research

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Research trail→

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Exercise training improves cardiac function and attenuates arrhythmia in CPVT mice.PMID 23042908Read ↗

Prevention of ventricular arrhythmia and calcium dysregulation in a catecholaminergic polymorphic ventricular tachycardia mouse model carrying calsequestrin-2 mutation.Semantic proximity Read ↗

Calsequestrin 2 (CASQ2) mutations increase expression of calreticulin and ryanodine receptors, causing catecholaminergic polymorphic ventricular tachycardia.Semantic proximity Read ↗

Exercise training prevents ventricular tachycardia in CPVT1 due to reduced CaMKII-dependent arrhythmogenic Ca2+ release.Semantic proximity Read ↗

The cardiac ryanodine receptor luminal Ca2+ sensor governs Ca2+ waves, ventricular tachyarrhythmias and cardiac hypertrophy in calsequestrin-null mice.Semantic proximity Read ↗

A mutation in calsequestrin, CASQ2D307H, impairs Sarcoplasmic Reticulum Ca2+ handling and causes complex ventricular arrhythmias in miceSemantic proximity Read ↗

Calsequestrin 2 and arrhythmias.Semantic proximity Read ↗

Casq2 deletion causes sarcoplasmic reticulum volume increase, premature Ca2+ release, and catecholaminergic polymorphic ventricular tachycardia.Semantic proximity Read ↗

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Familial hypertrophic cardiomyopathy-linked mutant troponin T causes stress-induced ventricular tachycardia and Ca2+-dependent action potential remodeling.Semantic proximity Read ↗

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