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Article

CaMKII Phosphorylation of RYR2 is Essential for Arrhythmia in CPVT

2025-09-18

Abstract excerpt

<h4>ABSTRACT</h4> <h4>Background</h4> Gain of function variants (GOF) in the intracellular calcium (Ca 2+ ) release channel RYR2 predominately underlie the inherited arrhythmogenic syndrome catecholaminergic polymorphic ventricular tachycardia (CPVT). Patients with CPVT are susceptible to life-threatening ventricular arrhythmias triggered by emotional or physical stress. Adrenergic stimulation activates calciu...

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Literature Corpus work
c4ac5fd2-c62b-57c0-9b78-30f32cfce71a
DOI
10.1101/2025.09.15.676430
Open publication

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