Subclinical abnormalities in sarcoplasmic reticulum Ca(2+) release promote eccentric myocardial remodeling and pump failure death in response to pressure overload.

doi:10.1016/j.jacc.2013.11.010

Article

Subclinical abnormalities in sarcoplasmic reticulum Ca(2+) release promote eccentric myocardial remodeling and pump failure death in response to pressure overload.

Journal of the American College of Cardiology - 22 Apr 2014

Sedej Simon, Schmidt Albrecht, Denegri Marco, Walther Stefanie, Matovina Marinko, Arnstein Georg, Gutschi Eva-Maria, Windhager Isabella, Ljubojević Senka, Negri Sara, Heinzel Frank R, Bisping Egbert, Vos Marc A, Napolitano Carlo, Priori Silvia G, Kockskämper Jens, Pieske Burkert

Abstract excerpt

OBJECTIVES: This study sought to explore whether subclinical alterations of sarcoplasmic reticulum (SR) Ca(2+) release through cardiac ryanodine receptors (RyR2) aggravate cardiac remodeling in mice carrying a human RyR2(R4496C+/-) gain-of-function mutation in response to pressure overload. BACKGROUND: RyR2 dysfunction causes increased diastolic SR Ca(2+) release associated with arrhythmias and contractile...

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Subclinical abnormalities in sarcoplasmic reticulum Ca(2+) release promote eccentric myocardial remodeling and pump failure death in response to pressure overload.

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