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Article

Catecholaminergic polymorphic ventricular tachycardia is caused by mutation-linked defective conformational regulation of the ryanodine receptor.

Circulation research - 30 Apr 2010

Uchinoumi Hitoshi, Yano Masafumi, Suetomi Takeshi, Ono Makoto, Xu Xiaojuan, Tateishi Hiroki, Oda Tetsuro, Okuda Shinichi, Doi Masahiro, Kobayashi Shigeki, Yamamoto Takeshi, Ikeda Yasuhiro, Ohkusa Tomoko, Ikemoto Noriaki, Matsuzaki Masunori

Abstract excerpt

RATIONALE: Catecholaminergic polymorphic ventricular tachycardia (CPVT) is caused by a single point mutation in a well-defined region of the cardiac type 2 ryanodine receptor (RyR)2. However, the underlying mechanism by which a single mutation in such a large molecule produces drastic effects on...

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Identifiers

PMID: 20224043
DOI: 10.1161/CIRCRESAHA.109.209312
PMCID: PMC2862146

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-20224043-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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