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Article

TonEBP suppresses IL-10-mediated immunomodulation.

Scientific reports - 10 May 2016

Choi Soo Youn, Lee Hwan Hee, Lee Jun Ho, Ye Byeong Jin, Yoo Eun Jin, Kang Hyun Je, Jung Gyu Won, An Seung Min, Lee-Kwon Whaseon, Chiong Mario, Lavandero Sergio, Kwon Hyug Moo

Abstract excerpt

TonEBP is a key transcriptional activator of M1 phenotype in macrophage, and its high expression is associated with many inflammatory diseases. During the progression of the inflammatory responses, the M1 to M2 phenotypic switch enables the dual role of macrophages in controlling the initiation and resolution of inflammation. Here we report that in human and mouse M1 macrophages TonEBP suppresses IL-10 expression...

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Identifiers

PMID: 27160066
DOI: 10.1038/srep25726
PMCID: PMC4861964

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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