Article
TIPE2 deficiency accelerates neointima formation by downregulating smooth muscle cell differentiation.
Cell cycle (Georgetown, Tex.) - 1 Feb 2013
Zhang Guizhong, Zhang Wenqian, Lou Yunwei, Xi Wenjin, Cui Jian, Geng Minghong, Zhu Faliang, Chen Youhai H, Liu Suxia
Abstract excerpt
Phenotypic switching of vascular smooth muscle cells (VSMCs) is known to play a key role in the development of atherosclerosis. However, the mechanisms that mediate VSMC phenotypic switching are unclear. We report here that TIPE2, the tumor necrosis factor (TNF) α-induced protein 8-like 2 (TNFAIP8L2), plays an atheroprotective role by regulating phenotypic switching of VSMCs in response to oxidized low-density...
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