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Article

Tie2 signaling cooperates with TNF to promote the pro-inflammatory activation of human macrophages independently of macrophage functional phenotype.

PloS one - 1 Jan 2014

García Samuel, Krausz Sarah, Ambarus Carmen A, Fernández Beatriz Malvar, Hartkamp Linda M, van Es Inge E, Hamann Jörg, Baeten Dominique L, Tak Paul P, Reedquist Kris A

Abstract excerpt

Angiopoietin (Ang) -1 and -2 and their receptor Tie2 play critical roles in regulating angiogenic processes during development, homeostasis, tumorigenesis, inflammation and tissue repair. Tie2 signaling is best characterized in endothelial cells, but a subset of human and murine circulating monocytes/macrophages essential to solid tumor formation express Tie2 and display immunosuppressive properties consistent...

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Source

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Identifiers

PMID: 24404127
DOI: 10.1371/journal.pone.0082088
PMCID: PMC3880273

Genes

TNF
CXCL3
CXCL5
CXCL8

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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