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Article

The m6A Reader IGF2BP2 Regulates Macrophage Phenotypic Activation and Inflammatory Diseases by Stabilizing TSC1 and PPARγ.

Advanced science (Weinheim, Baden-Wurttemberg, Germany) - 1 Jul 2021

Wang Xia, Ji Yuge, Feng Panpan, Liu Rucheng, Li Guosheng, Zheng Junjie, Xue Yaqiang, Wei Yaxun, Ji Chunyan, Chen Dawei, Li Jingxin

Abstract excerpt

Phenotypic polarization of macrophages is regulated by a milieu of cues in the local tissue microenvironment. Currently, little is known about how the intrinsic regulators modulate proinflammatory (M1) versus prohealing (M2) macrophages activation. Here, it is observed that insulin-like growth factor 2 messenger RNA (mRNA)-binding protein 2 (IGF2BP2)-deleted macrophages exhibit enhanced M1 phenotype and promote...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 34258163
DOI: 10.1002/advs.202100209
PMCID: PMC8261491

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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