Article
Myeloid cell-derived inducible nitric oxide synthase suppresses M1 macrophage polarization.
Nature communications - 27 Mar 2015
Lu Geming, Zhang Ruihua, Geng Shuo, Peng Liang, Jayaraman Padmini, Chen Chun, Xu Feifong, Yang Jianjun, Li Qin, Zheng Hao, Shen Kimberly, Wang Juan, Liu Xiyu, Wang Weidong, Zheng Zihan, Qi Chen-Feng, Si Chuanping, He John Cijiang, Liu Kebin, Lira Sergio A, Sikora Andrew G, Li Liwu, Xiong Huabao
Abstract excerpt
Here we show that iNOS-deficient mice display enhanced classically activated M1 macrophage polarization without major effects on alternatively activated M2 macrophages. eNOS and nNOS mutant mice show comparable M1 macrophage polarization compared with wild-type control mice. Addition of N6-(1-iminoethyl)-L-lysine dihydrochloride, an iNOS inhibitor, significantly enhances M1 macrophage polarization while...
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