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Article

IL-10 is required for polarization of macrophages to M2-like phenotype by mycobacterial DnaK (heat shock protein 70).

Cytokine - 1 Sept 2016

Lopes Rafael L, Borges Thiago J, Zanin Rafael F, Bonorino Cristina

Abstract excerpt

Macrophages are key cells in the innate immune system. They phagocytose pathogens and cellular debris, promote inflammation, and have important roles in tumor immunity. Depending on the microenvironment, macrophages can polarize to M1 (inflammatory) or M2 (anti-inflammatory) phenotypes. Extracellular DnaK (the bacterial ortholog of the mammalian Hsp70) from Mycobacterium tuberculosis (Mtb) was described to exert...

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Identifiers

PMID: 27337694
DOI: 10.1016/j.cyto.2016.06.018

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