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Article

Mediator 1 Is Atherosclerosis Protective by Regulating Macrophage Polarization.

Arteriosclerosis, thrombosis, and vascular biology - 1 Aug 2017

Bai Liang, Li Zhao, Li Qianwei, Guan Hua, Zhao Sihai, Liu Ruihan, Wang Rong, Zhang Jin, Jia Yuzhi, Fan Jianglin, Wang Nanping, Reddy Janardan K, Shyy John Y-J, Liu Enqi

Abstract excerpt

OBJECTIVE: MED1 (mediator 1) interacts with transcription factors to regulate transcriptional machinery. The role of MED1 in macrophage biology and the relevant disease state remains to be investigated. APPROACH AND RESULTS: To study the molecular mechanism by which MED1 regulates the M1/M2 phenotype switch of macrophage and the effect on atherosclerosis, we generated MED1/apolipoprotein E (ApoE) double-deficient...

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Source

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Identifiers

PMID: 28642237
DOI: 10.1161/ATVBAHA.117.309672
PMCID: PMC5739054

Genes

MED1
LDLR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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