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Nuclear receptor corepressor 1 deficiency exacerbates asthma by modulating macrophage polarization

29 Nov 2023

Abstract excerpt

Macrophage polarization plays an important role in asthma. Nuclear receptor corepressor 1 (NCOR1) plays an important role in metabolic and cardiovascular diseases by regulating the function of macrophages. The aim of this research was to examine the role and mechanism of macrophage NCOR1 in the development of asthma. We used ovalbumin (OVA) to induce macrophage NCOR1-deficient mice for asthma formation. Our...

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PMID: 38030614
DOI: 10.1038/s41420-023-01724-3

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