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Article

An Efficient Nonlinear Regression Approach for Genome-wide Detection of Marginal and Interacting Genetic Variations.

Journal of computational biology : a journal of computational molecular cell biology - 1 May 2016

Lee Seunghak, Lozano Aurélie, Kambadur Prabhanjan, Xing Eric P

Abstract excerpt

Genome-wide association studies have revealed individual genetic variants associated with phenotypic traits such as disease risk and gene expressions. However, detecting pairwise interaction effects of genetic variants on traits still remains a challenge due to a large number of combinations of variants (∼10(11) SNP pairs in the human genome), and relatively small sample sizes (typically <10(4)). Despite recent...

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PMID: 27159633
DOI: 10.1089/cmb.2015.0202
PMCID: PMC4876555

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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