Article
iRUNNER: A Baseline Mutation Burden Regression for Identifying Gene Interaction Between Rare Variants for Diseases.
Genomics, proteomics & bioinformatics - 22 Dec 2025
Jiang 江慧 Hui, Tang 唐斌 Bin, Li 李堃 Kun, Zhang 张柳彬 Liubin, Liang 梁俊豪 Junhao, Tang Clara Sze-Man, Tam Paul Kwong-Hang, Wang Binbin, Song 宋又强 Youqiang, Wang 王强 Qiang, Li 李俊 Mulin Jun, Huang 黄海亮 Hailiang, Li 李淼新 Miaoxin
Abstract excerpt
Genetic interactions play a crucial role in elucidating the susceptibility and etiology of complex multifactorial diseases. Despite significant efforts to identify disease-associated nonlinear effects in genome-wide association studies, efficient methods for detecting the epistatic impact of rare variants remain lacking. In this study, we propose iRUNNER, a novel and powerful mutation burden test focused on...
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