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Article

Gene-gene interaction detection with deep learning.

Communications biology - 12 Nov 2022

Cui Tianyu, El Mekkaoui Khaoula, Reinvall Jaakko, Havulinna Aki S, Marttinen Pekka, Kaski Samuel

Abstract excerpt

The extent to which genetic interactions affect observed phenotypes is generally unknown because current interaction detection approaches only consider simple interactions between top SNPs of genes. We introduce an open-source framework for increasing the power of interaction detection by considering all SNPs within a selected set of genes and complex interactions between them, beyond only the currently...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Polymorphism, Single Nucleotide

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Identifiers

PMID: 36371468
DOI: 10.1038/s42003-022-04186-y
PMCID: PMC9653457

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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