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Article

Detection of Germline Mutation in Hereditary Breast and/or Ovarian Cancers by Next-Generation Sequencing on a Four-Gene Panel.

The Journal of molecular diagnostics : JMD - 1 Jul 2016

Kwong Ava, Shin Vivian Y, Au Chun H, Law Fian B F, Ho Dona N, Ip Bui K, Wong Anthony T C, Lau Silvia S, To Rene M Y, Choy Gigi, Ford James M, Ma Edmond S K, Chan Tsun L

Abstract excerpt

Mutation in BRCA1/BRCA2 genes accounts for 20% of familial breast cancers, 5% to 10% of which may be due to other less penetrant genes which are still incompletely studied. Herein, a four-gene panel was used to examine the prevalence of BRCA1, BRCA2, TP53, and PTEN in hereditary breast and ovarian cancers in Southern Chinese population. In this cohort, 948 high-risk breast and/or ovarian patients were recruited...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 27157322
DOI: 10.1016/j.jmoldx.2016.03.005

Genes

BRCA1
BRCA2
PTEN

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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