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Prevalence and clinical impact of TP53 germline mutations in Chinese women with breast cancer

22 May 2019

Abstract excerpt

The prevalence and clinical relevance of TP53 germline mutations in a large unselected breast cancer series are largely unknown. Here, we determined TP53 germline mutations in a large cohort of 10,053 unselected breast cancer patients through multigene panel-based next-generation and/or Sanger sequencing assays. We found that 0.5% of patients (50 cases) carried a pathogenic TP53 germline mutation in this large...

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PMID: 31119730
DOI: 10.1002/ijc.32424

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