Article
The spectrum of BRCA mutations and characteristics of BRCA-associated breast cancers in China: Screening of 2,991 patients and 1,043 controls by next-generation sequencing.
International journal of cancer - 1 Jul 2017
Lang Guan-Tian, Shi Jin-Xiu, Hu Xin, Zhang Chen-Hui, Shan Ling, Song Chuan-Gui, Zhuang Zhi-Gang, Cao A-Yong, Ling Hong, Yu Ke-Da, Li Shan, Sun Meng-Hong, Zhou Xiao-Yan, Huang Wei, Shao Zhi-Ming
Abstract excerpt
To characterize the prevalence of BRCA mutations and characteristics of BRCA carriers in China and to update the clinical recommendations for BRCA testing, we conducted a wide screen for BRCA mutations using next-generation sequencing (NGS). A total of 4,034 Chinese subjects were screened for germline BRCA1/2 mutations, including 2,991 breast cancer patients and 1,043 healthy individuals from the community...
Topics
- Adult
- Aged
- Aged, 80 and over
- Asian People
- BRCA1 Protein
- BRCA2 Protein
- Breast Neoplasms
- China
- Disease-Free Survival
- Female