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Analysis of BRCA1/2 mutation spectrum and prevalence in unselected Chinese breast cancer patients by next-generation sequencing.

Journal of cancer research and clinical oncology - 1 Oct 2017

Li Guoli, Guo Xinwu, Tang Lili, Chen Ming, Luo Xipeng, Peng Limin, Xu Xunxun, Wang Shouman, Xiao Zhi, Yi Wenjun, Dai Lizhong, Wang Jun

Abstract excerpt

PURPOSE: BRCA1 and BRCA2 (BRCA1/2) are two major high-penetrance breast cancer predisposition genes, mutations in which can lead to high risks and early onset of breast cancer. This study was performed to comprehensively investigate the spectrum and prevalence of BRCA1/2 mutations in unselected Chinese breast cancer patients and evaluate the associations of BRCA1/2 mutations with related clinicopathological...

Topics

Asian People
BRCA1 Protein
BRCA2 Protein
Breast Neoplasms
Female
Genes, BRCA1
Genes, BRCA2
Genetic Predisposition to Disease
Germ-Line Mutation
High-Throughput Nucleotide Sequencing

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Humans

Microfluidic Analytical Techniques

Middle Aged

Polymerase Chain Reaction

Prevalence

Source

Identifiers

PMID: 28664449
DOI: 10.1007/s00432-017-2465-8

Genes

BRCA1
BRCA2

Variants

Provenance

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