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Pedigree analysis exploring the inconsistency between diverse phenotypes and testing criteria for germline TP53 mutations in Chinese women with breast cancer.

Breast cancer research and treatment - 1 Aug 2024

Huang Xin, Chen Chang, Lin Yan, Wang Changjun, Zhou Xingtong, Xu Ying, Sun Qiang, Zhou Yidong

Abstract excerpt

PURPOSE: In the present study, we addressed the inconsistency between the testing criteria and diverse phenotypes for germline TP53 mutation in patients with breast cancer in the Chinese population. METHOD: We proposed a new added item (synchronous or metachronous bilateral breast cancer) as one of the testing criteria (aimed at high-penetrance breast cancer susceptibility genes) and applied it for determining...

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Identifiers

PMID: 38878125
DOI: 10.1007/s10549-024-07341-7
PMCID: PMC11208215

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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