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Article

Prevalence and Spectrum of BRCA1/2 Germline Mutations in Women with Breast Cancer in China Based on Next-Generation Sequencing.

Medical science monitor : international medical journal of experimental and clinical research - 23 Apr 2018

Liang Yi, Yang Xuexi, Li Hong, Zhu Anna, Guo Zhiwei, Li Ming

Abstract excerpt

BACKGROUND BRCA1 and BRCA2 (BRCA1/2) play important roles in the development of breast cancer, but information regarding BRCA1/2 mutations in Chinese females remains limited. The aim of this study was to investigate the prevalence and spectrum of BRCA1/2 mutations in China. MATERIAL AND METHODS In total, 595 breast cancer patients in China were screened with an amplicon-based panel for the detection of BRCA1/2...

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Source

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Identifiers

PMID: 29681614
DOI: 10.12659/msm.905812
PMCID: PMC5936051

Genes

BRCA1
BRCA2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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