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Detection of Germline Mutations in Breast Cancer Patients with Clinical Features of Hereditary Cancer Syndrome Using a Multi-Gene Panel Test.

Cancer research and treatment - 1 Jul 2020

Shin Hee-Chul, Lee Han-Byoel, Yoo Tae-Kyung, Lee Eun-Shin, Kim Ryong Nam, Park Boyoung, Yoon Kyong-Ah, Park Charny, Lee Eun Sook, Moon Hyeong-Gon, Noh Dong-Young, Kong Sun-Young, Han Wonshik

Abstract excerpt

PURPOSE: Hereditary cancer syndrome means that inherited genetic mutations can increase a person's risk of developing cancer. We assessed the frequency of germline mutations using an next-generation sequencing (NGS)-based multiple-gene panel containing 64 cancer-predisposing genes in Korean breast cancer patients with clinical features of hereditary breast and ovarian cancer syndrome (HBOC). MATERIALS AND...

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Identifiers

PMID: 32019277
DOI: 10.4143/crt.2019.559
PMCID: PMC7373875

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