Article
Identification of a comprehensive spectrum of genetic factors for hereditary breast cancer in a Chinese population by next-generation sequencing.
PloS one - 1 Jan 2015
Yang Xiaochen, Wu Jiong, Lu Jingsong, Liu Guangyu, Di Genhong, Chen Canming, Hou Yifeng, Sun Menghong, Yang Wentao, Xu Xiaojing, Zhao Ying, Hu Xin, Li Daqiang, Cao Zhigang, Zhou Xiaoyan, Huang Xiaoyan, Liu Zhebin, Chen Huan, Gu Yanzi, Chi Yayun, Yan Xia, Han Qixia, Shen Zhenzhou, Shao Zhimin, Hu Zhen
Abstract excerpt
The genetic etiology of hereditary breast cancer has not been fully elucidated. Although germline mutations of high-penetrance genes such as BRCA1/2 are implicated in development of hereditary breast cancers, at least half of all breast cancer families are not linked to these genes. To identify a comprehensive spectrum of genetic factors for hereditary breast cancer in a Chinese population, we performed an...
Topics
- Adult
- Age of Onset
- Asian People
- Breast Neoplasms
- China
- Computational Biology
- DNA-Binding Proteins
- Epistasis, Genetic
- Female