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Rapid detection of genetic mutations in individual breast cancer patients by next-generation DNA sequencing.

Human genomics - 8 Feb 2015

Liu Suqin, Wang Hongjiang, Zhang Lizhi, Tang Chuanning, Jones Lindsey, Ye Hua, Ban Liying, Wang Aman, Liu Zhiyuan, Lou Feng, Zhang Dandan, Sun Hong, Dong Haichao, Zhang Guangchun, Dong Zhishou, Guo Baishuai, Yan He, Yan Chaowei, Wang Lu, Su Ziyi, Li Yangyang, Huang Xue F, Chen Si-Yi, Zhou Tao

Abstract excerpt

Breast cancer is the most common malignancy in women and the leading cause of cancer deaths in women worldwide. Breast cancers are heterogenous and exist in many different subtypes (luminal A, luminal B, triple negative, and human epidermal growth factor receptor 2 (HER2) overexpressing), and each subtype displays distinct characteristics, responses to treatment, and patient outcomes. In addition to varying...

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Identifiers

PMID: 25757876
DOI: 10.1186/s40246-015-0024-4
PMCID: PMC4348109

Genes

BRAF
GNAS
IDH1
KRAS
PTEN

Provenance

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