Article
A Deletion in the Canine POMC Gene Is Associated with Weight and Appetite in Obesity-Prone Labrador Retriever Dogs.
Cell metabolism - 10 May 2016
Raffan Eleanor, Dennis Rowena J, O'Donovan Conor J, Becker Julia M, Scott Robert A, Smith Stephen P, Withers David J, Wood Claire J, Conci Elena, Clements Dylan N, Summers Kim M, German Alexander J, Mellersh Cathryn S, Arendt Maja L, Iyemere Valentine P, Withers Elaine, Söder Josefin, Wernersson Sara, Andersson Göran, Lindblad-Toh Kerstin, Yeo Giles S H, O'Rahilly Stephen
Abstract excerpt
Sequencing of candidate genes for obesity in Labrador retriever dogs identified a 14 bp deletion in pro-opiomelanocortin (POMC) with an allele frequency of 12%. The deletion disrupts the β-MSH and β-endorphin coding sequences and is associated with body weight (per allele effect of 0.33 SD), adiposity, and greater food motivation. Among other dog breeds, the deletion was only found in the closely related...
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