Article

Master of none: <i>GPRC6A</i> gene loss is more widespread than previously known

2025-11-16

Abstract excerpt

GPRC6A encodes a class C GPCR that can be activated by multiple ligands and potentially acts as a central regulator of diverse metabolic processes by modulating endocrine pathways. Experimental studies have reported numerous distinct functions for GPRC6A , suggesting it may be a key drug target for several metabolic disorders. Yet, the actual function of GPRC6A has been the focus of considerable debate due to co...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 3b5cddec-77be-5670-8dbc-22d9459bba17
DOI: 10.1101/2025.11.14.688574

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Master of none: <i>GPRC6A</i> gene loss is more widespread than previously knownDOI 10.1101/2025.11.14.688574Read

The emerging roles of GPRC5A in diseasesSemantic proximity Read

Diversity in chemosensory receptor genes in dogs and wolves: degeneration of the olfactory receptor gene repertoire in the brachycephalic Pug.Semantic proximity Read

Evolutionary constraint and innovation across hundreds of placental mammalsSemantic proximity Read

Loss of critical developmental and human disease-causing genes in 58 mammalsSemantic proximity Read

Mutations in G Protein-Coupled Receptors: Mechanisms, Pathophysiology and Potential Therapeutic Approaches.Semantic proximity Read

Rare variant pathogenicity triage and inclusion of synonymous variants improves analysis of disease associationsSemantic proximity Read

The Evolution of the Mammalian ABCA6-like Genes: Analysis of Phylogenetic, Expression, and Population Genetic Data Reveals Complex Evolutionary Histories.Semantic proximity Read

Extreme variability among mammalian V1R gene families.Semantic proximity Read

Dramatic variation of the vomeronasal pheromone receptor gene repertoire among five orders of placental and marsupial mammals.Semantic proximity Read

Integrated Approaches for Genome-wide Interrogation of the Druggable Non-olfactory G Protein-coupled Receptor SuperfamilySemantic proximity Read

Evolution of the α <sub>2</sub> -adrenoreceptors in vertebrates: ADRA2D is absent in mammals and crocodilesSemantic proximity Read

Implications of gen(om)e duplications on the expansion and evolution of the GPCR signalling pathwaySemantic proximity Read