Article
Melanocortin 1 receptor variation in the domestic dog.
Mammalian genome : official journal of the International Mammalian Genome Society - 1 Jan 2000
Newton J M, Wilkie A L, He L, Jordan S A, Metallinos D L, Holmes N G, Jackson I J, Barsh G S
Abstract excerpt
The melanocortin 1 receptor (Mc1r) is encoded by the Extension locus in many different mammals, where a loss-of-function causes exclusive production of red/yellow pheomelanin, and a constitutively activating mutation causes exclusive production of black/brown eumelanin. In the domestic dog, breeds with a wild-type E allele, e. g., the Doberman, can produce either pigment type, whereas breeds with the e allele,...
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