Article
Canine genome-wide association study identifies DENND1B as an obesity gene in dogs and humans.
Science (New York, N.Y.) - 28 Mar 2025
Wallis Natalie J, McClellan Alyce, Mörseburg Alexander, Kentistou Katherine A, Jamaluddin Aqfan, Dowsett Georgina K C, Schofield Ellen, Morros-Nuevo Anna, Saeed Sadia, Lam Brian Y H, Sumanasekera Natasha T, Chan Justine, Kumar Sambhavi S, Zhang Rey M, Wainwright Jodie F, Dittmann Marie, Lakatos Gabriella, Rainbow Kara, Withers David, Bounds Rebecca, Ma Marcella, German Alexander J, Ladlow Jane, Sargan David, Froguel Philippe, Farooqi I Sadaf, Ong Ken K, Yeo Giles S H, Tadross John A, Perry John R B, Gorvin Caroline M, Raffan Eleanor
Abstract excerpt
Obesity is a heritable disease, but its genetic basis is incompletely understood. Canine population history facilitates trait mapping. We performed a canine genome-wide association study for body condition score-a measure of obesity-in 241 Labrador retrievers. Using a cross-species approach, we showed that canine obesity genes are also associated with rare and common forms of obesity in humans. The lead canine...
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