Article
Excess maternal transmission of variants in the THADA gene to offspring with type 2 diabetes.
Diabetologia - 1 Aug 2016
Prasad Rashmi B, Lessmark Anna, Almgren Peter, Kovacs Györgyi, Hansson Ola, Oskolkov Nikolay, Vitai Marta, Ladenvall Claes, Kovacs Peter, Fadista Joao, Lachmann Michael, Zhou Yuedan, Sonestedt Emily, Poon Wenny, Wollheim Claes B, Orho-Melander Marju, Stumvoll Michael, Tuomi Tiinamaija, Pääbo Svante, Koranyi Laszlo, Groop Leif
Abstract excerpt
AIMS/HYPOTHESIS: Genome-wide association studies (GWAS) have identified more than 65 genetic loci associated with risk of type 2 diabetes. However, the contribution of distorted parental transmission of alleles to risk of type 2 diabetes has been mostly unexplored. Our goal was therefore to search for parent-of-origin effects (POE) among type 2 diabetes loci in families. METHODS: Families from the Botnia study...
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